Production of Lyophilized Kits for Labelling with Tc

99m The use of Tc-DTPA is for brain imaging renal flow study, and glomerular filtration rate measurement. Following intravenous injection, 99mTc-DTPA is rapidly cleared from the blood by glomerular filtration. Renal retention is 7% of the injected dose at 1 h and 95% is excreted within 24 h. It is neither secreted nor reabsorbed by the tubules and has negligible biliary excretion and elimination in feces. When the blood-brain barrier is compromised, 99m 99mTc-DTPAaccumulates in the brain lesions. To prepare Tc-DTPA injection, the recommended maximum amount of 99mTc to be added to a reaction vials is 37000MBq (100 mCi). The dose range for intravenous injection to the average adult patient (70 Kg) is: brain imaging 555 to 740 MBq (15 to 20 mCi); kidney imaging and Glomerular Filtration Rate 74 to 185 MBq (2 to 5 mCi).